Nimesulide induced bullous fixed drug eruption of the labial mucosa.

44 Serum sickness classically refers to a systemic immunological reaction caused by injected serum and occurs due to deposition of an antigen-antibodycomplement complex. It occurs when an antigen (i.e. serum) persists in the circulation for a long duration stimulating IgG or IgM antibody synthesis. These antibodies, along with complement, form complexes which are deposited in various organs. The manifestations develop according to the organ involved. Since heterologous serum is rarely used, such a systemic reaction due to serum is rare. Other causes like drugs are now more commonly implicated and the resultant reaction is called a serum sickness like reaction. Minocycline can cause such a reaction rarely.